top of page
Snake

Publications

Image by Braňo

Targeting cobra venom cytotoxin: a linear 40-mer ssDNA aptamer-based antivenom confers neutralisation potentials against cobra venom-induced cytotoxicity

A modified selection and sequencing workflow to discover the potential of 40T as aptamer-based antivenom to mitigate venom-induced dermonecrosis.

Yap MKK (2025). Technical Report: Cytotoxicity and Cyanotoxins profiling of Tasik Taman Aman. Monash University. Report. https://doi.org/10.26180/28868423.v1

Mohamad Norpi N, Chang LW, Yap MKK, Jang F, Yeong HY, Mat Jalaluddin NS, Md Kasim A, Fakri MFR, Nasaruddin A, Idris N, Abd Kadir SN (2024). Handbook on Guarding Our Water Together. University of Malaya, Kuala Lumpur, Malaysia.

​

 

 

 

​

​

  • ​Zabidi NZ, Misuan N, Farouk IA, Lal SK, Yap MKK (2024). Therapeutic applications of snake venom proteins as anti-cancer agents. In R.C. Sobti et al. (Eds), Molecular Biomarkers for Cancer Diagnosis and Therapy. Springer, Singapore. https://doi.org/10.1007/978-981-99-3746-2_32

  • Yong Y, Hiu JJ, Yap MKK (2022). The secretory phenotypes of envenomed cells: Insights into venom cytotoxicity. Advances in Protein Chemistry and Structural Biology – Secretory Proteins. Donev, R. (ed). Academic Press, In Press.​

  • Yap MKK, Misuan N (2021). Exendin-4 and its related proteins. In S. Mackessy (Ed.), Handbook of Venoms and Toxins of Reptiles(Second ed., pp. 251-269). Florida, United States: CRC Press.

​

​

Yap MKK, Modahl CM, Hall SR (2024). Editorial: Experimental and computational aspects of bioactive proteins from animal venoms: an insight into pharmacological properties and drug discovery. Frontiers in Pharmacology. 15, 3, 1380193. https://doi.org/10.3389/fphar.2024.1380193

  • ​​​Hiu JJ, Tan HS, Yap MKK (2025). Targeting cobra venom cytotoxin: a linear 40-mer ssDNA aptamer-based antivenom confers neutralisation potentials against cobra venom-induced cytotoxicity. Arch Toxicol. https://doi.org/10.1007/s00204-025-04211-z.

  • Chan VJW, Chang LW, Jang FH, Razak MS, Yap MKK (2025). A spatiotemporal study of a recreational freshwater lake: ultraperformance liquid chromatography–tandem mass spectrometry profiling of cyanotoxins and the dermal toxicity assessment, Environ Toxicol Chem. vgaf227, https://doi.org/10.1093/etojnl/vgaf227.

  • Yong Y, Yap MKK (2025). Annexin A2 is a potential membrane protein target of cobra venom cytotoxin. Toxicon. 264, 108452.

  • Hiu JJ, Tan HS, Yap MKK (2025). The neutralisation and inhibitory effects of new tRNA-mimetic aptamer against cytotoxin-induced cytotoxicity in human skin keratinocytes. Biochimie, 231: 116–126 https://doi.org/10.1016/j.biochi.2024.12.011 

  • Chang LW, Yap MKK (2025). Guarding our water together: the silent threats and sustainable solutions of cyanotoxins monitoring in freshwater. Biochem (Lond) bio_2024_940.  bio_2024_940. https://doi.org/10.1042/bio_2024_940

  • Ding SM, Yap MKK (2024) Deciphering toxico-proteomics of Asiatic medically significant venomous snake species: A systematic review and interactive data dashboard. Toxicon, 250 (21): 108120. 

  • Lim EQ, Ahemad N, Yap MKK (2023). High-throughput virtual screening, pharmacophore modelling and antagonist effects of small molecule inhibitors against cytotoxin-induced cytotoxicity. Journal of Biomolecular Structures and Dynamics. https://doi.org/10.1080/07391102.2023.2293275  

  • Hiu JJ, Fung JKY, Tan HS, Yap MKK (2023). Unveiling the functional epitopes of cobra venom cytotoxin by
    immunoinformatics and epitope-omic analyses. Scientific Reports 13, 12271. https://doi.org/10.1038/s41598-023-39222-2

  • Misuan N, Mohamad S, Tubiana T, Yap MKK (2023). Ensemble-based molecular docking and spectrofluorometric analysis of interaction between cytotoxin and tumor necrosis factor receptor 1. Journal of Biomolecular Structure and Dynamics. 6, 1-15. https://doi.org/10.1080/07391102.2023.2188945

  • Selvam R, Lim IHY, Lewis JC, Lim CH, Yap MKK, Tan HS (2023).  Selecting antibacterial aptamers against the BamA protein in Pseudomonas aeruginosa by incorporating genetic algorithm to optimise computational screening method. Scientific Reports. 13, 7582. https://doi.org/10.1038/s41598-023-34643-5

  • Quek WP, Ong YH, Yap MKK, Lee YY, Karim NAA, Chan ES (2023). A comparative study of the oxidative
    stability and the formation of monochloropropanediol esters (MCPDE) and glycidyl esters (GE) between
    physically and chemically refined palm olein during repeated deep-frying. Food Control. 150, 109737.

  • Quek WP, Ong YH, Yap MKK, Lee YY, Ab Karim NA, Chew CL, Chan ES (2023). The effects of quality changes in vegetable oils on the formation and absorption of monochloropropanediol esters (MCPDE) and glycidyl esters (GE) during deep-frying of potato chips. Food Control. 149, 109699.

  • Foo SC, Lee ZS, Yap MKK, Tan JW (2023). The antioxidant, wound healing properties and proteomic analysis
    of water extracts from the tropical cyanobacteria, Nostoc NIES-2111_MUM004. 3 Biotech 13, 71 (2023). https://doi.org/10.1007/s13205-022-03448-0

  • Quek WP, Yap MKK, Lee YY, Hock Ong AS, Chan ES (2022). Systematic comparison on the deep-frying performance of different vegetable oils from literature data using the rate of parameter change approach. Food Control. 137, 8, 108922.

  • Hiu JJ, Yap MKK (2022). The myth of cobra venom cytotoxin: More than just direct cytolytic actions. Toxicon: X. 14, 10 100123.

  • Yap MKK. (2022). A digital module-based experiential learning in protein biochemistry during the COVID-19pandemic paradigm. Biochemistry and Molecular Biology Education. 51(1), 77-80.https://doi.org/10.1002/bmb.21680

  • Wong JF, Hong HJ, Foo SC, Yap MKK, Tan JW (2022). A review on current and future advancements for commercialized microalgae species. Food Science and Human Wellness. 11: 1156-1170. 

  • Hiu JJ, Yap MKK (2021). The effects of Naja sumatrana venom cytotoxin, sumaCTX on alteration of the secretome in MCF-7 breast cancer cells following membrane permeabilization. International Journal of Biological Macromolecules. 184: 776-786. 

  • Teoh SQ, Yap MKK (2020). Naja sumatrana venom cytotoxin, sumaCTX exhibits concentration-dependent cytotoxicity via caspase-activated mitochondrial-mediated apoptosis without transitioning to necrosis. Toxin Reviews. DOI: 10.1080/15569543.2020.1799408. 

  • Hiu JJ, Yap MKK (2020). Cytotoxicity of snake venom enzymatic toxins: phospholipase A2 and l-amino acid oxidase. Biochemical Society Transactions. 48:719-731. DOI: 1042/BST20200110.

  • Gurunanselage Don RAS, Yap MKK (2019). Arctium lappa L. root extract induces cell death via mitochondrial-mediated caspase-dependent apoptosis in Jurkat human leukemic T cells. Biomedicine & Pharmacotherapy. 110:918-929. 

  • Yap MKK, Misuan M (2019). Exendin-4 from Heloderma suspectum venom: From discovery to its latest application as Type II diabetes combatant. Basic & Clinical Pharmacology & Toxicology. 124:513–527. DOI: 10.1111/bcpt.13169. 

  • Tan CH, Tan KY, Yap MKK, Tan NH (2017). Venomics of Tropidolaemus wagleri, the sexually dimorphic temple pit viper: Unveiling a deeply conserved atypical toxin arsenal. Scientific Reports. DOI: 10.1038/srep43237.

  • Fung SY, Tan CH, Yap MKK, Leong PK, Liew JL, Tan NH (2016). Unveiling the elusive and exotic: Venomics of the Malayan blue coral snake (Calliophis bivirgata flaviceps). Journal of Proteomics, 132:1-12.

  • Tan NH, Fung SY, Tan KY, Yap MKK, Ariaranee C, Tan CH (2015). Functional venomics of the Sri Lankan Russell’s viper (Daboia russelii) and its toxinological correlations. Journal of Proteomics, 128:403-423.

  • Yap MKK, Tan NH, Sim SM, Fung SY and Tan CH (2015). The effect of a polyvalent antivenom on the serum venom antigen levels of Naja sputatrix (Javan spitting cobra) venom in experimentally envenomed rabbits. Basic & Clinical Pharmacology & Toxicology, 117(4):274-279.

  • Yap MKK, Tan NH, Sim SM, Fung SY and Tan CH (2014). Pharmacokinetics of Naja sumatrana (Equatorial spitting cobra) venom and its major toxins in experimentally envenomed rabbits. PloS Neglected Tropical Diseases. DOI:10.1371/journal.pntd.0002890.

  • Yap MKK, Fung SY, Tan KY and Tan NH (2014). Proteomic characterization of venom of the medically important Southeast Asian Naja sumatrana (Equatorial spitting cobra). Acta Tropica. 13: 15-25.

  • Yap MKK, Tan NH, Sim SM and Fung SY (2013). Toxicokinetics of Naja sputatrix (Javan spitting cobra) venom following intramuscular and intravenous administrations of the venom into rabbits. Toxicon. 68:18-23.

  • Yap MKK, Sim SM, Tan NH and Fung SY (2011). Pharmacokinetics of Naja sputatrix (spitting cobra) venom in rabbits. Journal of Pharmacological Sciences. 115: Supp1,183P.

  • Yap MKK, Tan NH and Fung SY (2011). Biochemical and toxinological characterization of Naja sumatrana (Equatorial spitting cobra) venom. Journal of Venomous Animal Toxins including Tropical Diseases. 17(4): 451-459.

  • ​​​​Hiu JJ, Tan HS, Yap MKK (2024) Epitope-Omics directed discovery of Apt6: Neutralisation effects against cobra venom. Toxicon, 248: 107870

  • Hiu JJ, Tan HS, Yap MKK (2022). In silico selection of aptamers to cobra venom cytotoxin. BMC Proceedings.

    16(Suppl 7), 46 – 47, P-54. https://doi.org/10.1186/s12919-022-00237-8

  • Selvam R, Yap MKK, Tan HS (2022). Selecting antibacterial aptamers against an essential outer membrane

    via aptamer repurposing. BMC Proceedings. 16 (Suppl 7), 38-39, P-33.Pseudomonas aeruginosa protein in

    https://doi.org/10.1186/s12919-022-00237-8 

  • Hiu JJ, Yap MKK.  Experimental and computational investigation of membrane perturbing effects of snake cytotoxin (SCT) family. 5th Prato Conference on Pore Forming Protein. 22 - 24 June 2021. 

  • Misuan N, Yap MKK. Structural characteristics, physicochemical properties, and domain architectures of cobra venom cytotoxin. 2021 ASBMB Protein Data Bank Symposium - 50th-year celebration. 4 - 5 May 2021.

  • Teoh SQ, Hiu JJ, Yap MKK. The myth of venom cytotoxin – more than just cytolytic actions. Oxford Venoms & Toxins 2020. 16 - 17 Sep 2020.

  • Misuan N, Mohammad S, Yap MKK. Molecular docking of cobra venom cytotoxin with death receptors. The 19th International Conference on Bioinformatics. 25 - 29 Nov 2021. â€‹

Join our mailing list for updates on publications and events

Thanks for submitting!

Monash University Malaysia, Jalan Lagoon Selatan, 47500 Bandar Sunway, Malaysia.

603-5514 5860

© 2025 by Toxin Pharmacology Lab. Proudly created with Wix.com

bottom of page